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Dosage and Administration

Tablet:

• 5mg
• 1mg
• 2mg

Oral concentrate

• 2mg/mL

Injectable solution

• 2mg/mL
• 4mg/mL

Ativan (lorazepam) is administered orally. For optimal results, dose, frequency of administration, and duration of therapy should be individualized according to patient response. To facilitate this, 0.5 mg, 1 mg, and 2 mg tablets are available and injectable solution are 2mm/ML,4mg/ML.The usual range is 2 to 6 mg/day given in divided doses, the largest dose being taken before bedtime, but the daily dosage may vary from 1 to 10 mg/day.

 

Side Effects

Call your doctor at once if you have:

• Difficulty breathing
• Swelling of your face, lips, tongue, or throat.
• Severe drowsiness
• ­Thoughts of suicide or hurting yourself
• Unusual changes in mood or behavior
• Confusion
• Aggression
• Hallucinations
• Worsened sleep problems
• Sudden restless feeling or excitement
• Muscle weakness
• Drooping eyelids
• Trouble swallowing
• Vision changes
• Upper stomach pain
• Dark urine
• Jaundice (yellowing of the skin or eyes).

 

Contraindications

• Myasthenia gravis
• Ativan Injection should not be used in patients with severe hepatic or pulmonary insufficiency
• Sleep apnoea syndrome
• Ativan Injection should not be given to patients with a previous history of sensitivity to benzodiazepines, or any of the recipients (propylene glycol, polyethylene glycol and benzyl alcohol
• Ativan Injection is not recommended for out-patient use unless the patient is accompanied.

Warnings  

Pre-existing depression may emerge or worsen during use of benzodiazepines including lorazepam(Ativan).As with all patients on CNS-depressant drugs, patients receiving lorazepam should be warned not to operate dangerous machinery or motor vehicles and that their tolerance for alcohol and other CNS depressants will be diminished.Ativan (lorazepam) is not recommended for use in patients with a primary depressive disorder or psychosis. Extreme care must be taken in administering Ativan Injection to elderly or very ill patients and to those with limited pulmonary reserve or compromised respiratory function (e.g. chronic obstructive pulmonary disease [COPD]), because of the possibility that apnoea and/or cardiac arrest may occur. Care should be taken when administering Ativan Injection to a patient with status epilepticus, especially when the patient has received other central nervous system depressants. Patients should remain under observation for at least eight hours and preferably overnight. When Ativan Injection is used for short procedures on an outpatient basis, the patient should be accompanied when discharged. Patients should be advised that their tolerance for alcohol and other CNS depressants will be diminished in the presence of Ativan Injection. Alcoholic beverages should not be consumed for at least 24 to 48 hours after receiving Ativan Injection. WIKI

NB:

• Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
• Limit dosages and durations to the minimum required.

Follow patients for signs and symptoms of respiratory depression and sedation.