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Dosage and Administration

Dosage forms: 5 mg, 10 mg, 15 mg

Narcolepsy (5-60 mg/day PO divided qd-bid)

Start: 10 mg PO qam, May incr. by 10 mg/day qwk; Max: 60 mg/day; Info: taper dose gradually to D/C if prolonged, high dose use

*ADHD (5-40 mg/day PO divided qd-bid)

Start: 5 mg PO qam or bid, may increase by 5 mg/day, Max: 60 mg/day;Info: duration 6-8h; doses >40 mg/day rarely more effective; taper dose gradually to D/C if prolonged, high dose use

*obesity, short-term tx[5-15 mg PO qam]

Max: 30 mg/day; Info: give 30-60min before meals; taper dose gradually to D/C if prolonged, high dose.

Side Effects

Agitation, delusions, Seeing, hearing, or feeling things that are not there

Blurred vision, chest discomfort or pain difficulty breathing, dizziness, faintness false or unusual sense of well-being fast, pounding, or irregular heartbeat or pulse headache, pounding in the ears, shakiness in the legs, arms, hands, or feet, swelling of the feet or lower legs, trembling or shaking of the hands or feet twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legsunable to sleep uncontrolled vocal outbursts and/or tics (uncontrolled repeated body movements) unusual tiredness or weakness

Contraindications

Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma. Agitated states: Patients with a history of drug abuse. During or within 14 days following the administration of monoamine oxidase inhibitors (hypertensive crises may result).

Warnings

Sudden death has been reported in association with CNS stimulant treatment at usual doses in children and adolescents with structural cardiac abnormalities or other serious heart problems. Although some serious heart problems alone carry an increased risk of sudden death, stimulant products generally should not be used in children or adolescents with known serious structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, or other serious cardiac problems that may place them at increased vulnerability to the sympathomimetic effects of a stimulant drug. Adults: Sudden deaths, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses for ADHD. Although the role of stimulants in these adult cases is also unknown, adults have a greater likelihood than children of having serious structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease, or other serious cardiac problems. Adults with such abnormalities should also generally not be treated with stimulant drugs. WIKI

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