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Dosage and Administration

Tablets: 2mg, 4mg and 8mg.

Oral solution: 5 mg/5 mL (1 mg/mL)

Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.

Usual adult dosage of DILAUDID Oral Solution is one-half (2.5 mL) to two teaspoonsful (10 mL) (2.5 mg – 10 mg) every 3 to 6 hours.

Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and misuse.

Usual adult starting dose for DILAUDID Tablets is 2 mg to 4 mg, orally, every 4 to 6 hours.

Hepatic Impairment

Initiate treatment with one-fourth to one-half the ususal starting dose, depending on degree of hepatic impairment.

Renal Impairment

Initiate treatment with one-fourth to one-half the usual starting dose, depending on degree of renal impairment

Side effects

• Tachycardia
• Hypotension
• CNS Depression
• Respiratory
• Depression
• Transient
• Hyperglycemia
• Dizziness
• Drowsiness
• Altered LOC
• Hallucinations
• Euphoria
• Mental Impairment
• Lightheadedness
• Bradycardia

Warnings

Respiratory depression is the chief hazard of DILAUDID ORAL LIQUID and DILAUDID TABLETS. Respiratory depression is more likely to occur in the elderly, in the debilitated, and in those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation. DILAUDID ORAL LIQUID and DILAUDID TABLETS should be used with extreme caution in patients with chronic obstructive pulmonary disease or cor pulmonale, patients having a substantially decreased respiratory reserve, hypoxia, hypercapnia, or in patients with preexisting respiratory depression. In such patients even usual therapeutic doses of opioid analgesics may decrease respiratory drive while simultaneously increasing airway resistance to the point of apnea. Wiki

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