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To be prescribed only by health care providers knowledgeable in use of potent opioids for management of chronic pain.

-Must swallow tablets intact. Do not cut, break, chew, crush, or dissolve tablets (risk of potentially fatal dose).

-Must take tablets one at a time, with enough water to ensure complete swallowing immediately after placing in mouth.

-OXYCONTIN 60 mg and 80 mg tablets, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are only for use in patients in whom tolerance to an opioid of comparable potency has been established.

-Do not abruptly discontinue OXYCONTIN in a physically dependent patient.

Adults: For opioid-naïve and opioid non-tolerant patients, initiate with 10 mg tablets orally every 12 hours. See full prescribing information for instructions on conversion from opioids to OXYCONTIN, titration and maintenance of therapy.

For use only in pediatric patients 11 years and older already receiving and tolerating opioids for at least 5 consecutive days with a minimum of 20 mg per day of oxycodone or its equivalent for at least two days immediately preceding dosing with OXYCONTIN

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Side Effects

Constipation,nausea,stomach pain,loss of appetite,vomiting,sleepiness,tiredness,drowsiness,dizziness,lightheadedness,weakness,itching,headache,dry mouth,sweating, and decreases in the ability to feel pain.respiratory depression,apnea (stopped breathing),respiratory arrest,circulatory depression,hypotension (low blood pressure),shock, and death.

Contraindications

In patients who have significant respiratory depression

In patients who have or are suspected of having paralytic ileus

In patients who have acute or severe bronchial asthma

In patients with known hypersensitivity to oxycodone

Warnings

Life-Threatening Respiratory Depression in Patients with Chronic

Pulmonary Disease or in Elderly, Cachectic, or Debilitated Patients:

Monitor closely, particularly during initiation and titration.

• Adrenal Insufficiency: If diagnosed, treat with physiologic replacement of corticosteroids, and wean patient off of the opioid.
• Severe Hypotension: Monitor during dosage initiation and titration. Avoid use of OXYCONTIN in patients with circulatory shock.
• Risks of Use in Patients with Increased Intracranial Pressure, Brain

Tumors, Head Injury, or Impaired Consciousness: Monitor for sedation and respiratory depression. Avoid use of OXYCONTIN in patients with impaired consciousness or coma.

• Risk of Obstruction in Patients who have Difficulty Swallowing or have

Underlying GI Disorders that may predispose them to Obstruction:

Consider use of an alternative analgesic. More info : WIKI

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