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Dosage and Administration

It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. Dosage should be adjusted according to the severity of the pain and the response of the patient. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. PERCOCET tablets are given orally.

Extended-release tablet: Swallow whole with enough water to ensure complete swallowing after placing in mouth; do not break, chew, cut, crush, dissolve or split the tablets

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Side Effects

• Lightheadedness
• Drowsiness or sedation
• Nausea and vomiting
• Euphoria
• Dysphoria
• Constipation
• Pruritus
• Skin and urticarial eruptions
• Fatal hepatic necrosis (rare; associated with high/chronic acetaminophen use)
• Renal tubular necrosis
• Dizziness

 

 

CONTRAINDICATIONS

PERCOCETS is contraindicated in patients with:

Significant respiratory depression.

Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipmentKnown or suspected gastrointestinal obstruction, including paralytic ileus.Hypersensitivity to oxycodone, acetaminophen, or any other component of the product (e.g., anaphylaxis)

 

Warnings

PERCOCET contains oxycodone, a Schedule II controlled substance. As an opioid, PERCOCET exposes users to the risks of addiction, abuse, and misuse.Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed PERCOCETS. Addiction can occur at recommended dosages and if the drug is misused or abused. Assess each patient’s risk for opioid addiction, abuse, or misuse prior to prescribing PERCOCET, and monitor all patients receiving PERCOCETS for the development of these behaviors and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as PERCOCET, but use in such patients necessitates intensive counseling about the risks and proper use of PERCOCET along with intensive monitoring for signs of addiction, abuse, and misuse.

Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing PERCOCET. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity and advising the patient on the proper disposal of unused drug [see PRECAUTIONS; Information for Patients/Caregivers]. Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product.WIKI

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